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Found 2 Enz. Inhib. hit(s) with Target = 'Macrophage metalloelastase' and Ligand = 'BDBM29018'
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  1.49E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  1.49E+5nM Kd:  1.54E+5nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair