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Found 4 Enz. Inhib. hit(s) with Target = 'Prostaglandin E synthase' and Ligand = 'BDBM50028856'
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataKi:  0.100nM IC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataIC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed