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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ITK/TSK' and Ligand = 'BDBM50257857'
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ITK (unknown origin) in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed