Compile Data Set for Download or QSAR
maximum 50k data
Found 32 Enz. Inhib. hit(s) with all data for entry = 50021051
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...)
Affinity DataIC50:  0.0200nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220383(4'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220379(3,2'-bis-trifluoromethyl-biphenyl-4-carbonitrile |...)
Affinity DataIC50: >1nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220389(2'-chloro-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50:  9.80nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220379(3,2'-bis-trifluoromethyl-biphenyl-4-carbonitrile |...)
Affinity DataIC50:  10.9nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220385(4'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  11.9nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220384(2',6'-dimethoxy-3-trifluoromethyl-biphenyl-4-carbo...)
Affinity DataIC50:  14.7nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220376(2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  20.1nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220376(2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  37nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...)
Affinity DataIC50:  39.9nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220383(4'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  56.7nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220385(4'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  61.2nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220388(3'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220375(2'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50:  146nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220382(4'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220380(3'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  229nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220384(2',6'-dimethoxy-3-trifluoromethyl-biphenyl-4-carbo...)
Affinity DataIC50:  399nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220382(4'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50:  843nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220388(3'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  955nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220377(2',6'-dihydroxy-3-trifluoromethyl-biphenyl-4-carbo...)
Affinity DataIC50:  989nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220375(2'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220381((4'-cyano-3'-trifluoromethyl-biphenyl-2-yloxy)-ace...)
Affinity DataIC50:  1.31E+3nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220387(2'-(2-hydroxy-ethoxy)-3-trifluoromethyl-biphenyl-4...)
Affinity DataIC50:  1.54E+3nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220386(3'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220391(2'-(2-methoxy-ethoxy)-3-trifluoromethyl-biphenyl-4...)
Affinity DataIC50:  2.23E+3nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220376(2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  3.25E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...)
Affinity DataIC50:  4.45E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220383(4'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  5.52E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220390(2'-[2-(2-methoxy-ethoxy)-ethoxy]-3-trifluoromethyl...)
Affinity DataIC50:  8.14E+3nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220388(3'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50:  9.46E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220385(4'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220378((4'-cyano-3'-trifluoromethyl-biphenyl-2-yloxy)-ace...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed