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Target
Cholinesterase
Ligand
BDBM10487
Substrate
n/a
Meas. Tech.
ChEMBL_2110045 (CHEMBL4818720)
IC50
311±n/a nM
Citation
 Gorecki, L; Misiachna, A; Damborsky, J; Dolezal, R; Korabecny, J; Cejkova, L; Hakenova, K; Chvojkova, M; Karasova, JZ; Prchal, L; Novak, M; Kolcheva, M; Kortus, S; Vales, K; Horak, M; Soukup, O Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors. Eur J Med Chem 219:0 (2021) [PubMed]  Article 
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
  
Inhibitor
Name:
BDBM10487
Synonyms:
1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-amine | 11-Amino-1-chloro-6H-cyclohepta[b]quinoline | Tacrine (THA) analogue 2
Type:
Small organic molecule
Emp. Form.:
C14H15ClN2
Mol. Mass.:
246.735
SMILES:
Nc1c2CCCCCc2nc2cccc(Cl)c12
Structure:
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