Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM50452609
Substrate
n/a
Meas. Tech.
ChEMBL_1747820 (CHEMBL4182330)
IC50
8.9±n/a nM
Citation
 Futamura-Takahashi, J; Tanaka, T; Sugawara, H; Iwashita, S; Imajo, S; Oyama, Y; Muto, T Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors. Bioorg Med Chem Lett 28:188-192 (2018) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50452609
Synonyms:
CHEMBL4206099
Type:
Small organic molecule
Emp. Form.:
C30H32ClN5O6
Mol. Mass.:
594.058
SMILES:
CC[C@@H](NC(=O)N1C\C(NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(C(O)=O)c(N)c1 |r|
Structure:
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