TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical
Curated by ChEMBL
Taiho Pharmaceutical
Curated by ChEMBL
Affinity DataKi: 1.80E+4nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 0.390nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 0.420nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 0.440nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 0.960nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 0.960nMAssay Description:Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Binding affinity to ghrelin receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secret...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellula...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant chymaseMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical
Curated by ChEMBL
Taiho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant chymaseMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Asubio Pharma
Curated by ChEMBL
Asubio Pharma
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Binding affinity to ghrelin receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant chymaseMore data for this Ligand-Target Pair
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical
Curated by ChEMBL
Taiho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysisMore data for this Ligand-Target Pair