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Target
Retinoic acid receptor RXR-gamma
Ligand
BDBM50508799
Substrate
n/a
Meas. Tech.
ChEMBL_1834361 (CHEMBL4334369)
EC50
22000±n/a nM
Citation
 Heitel, P; Gellrich, L; Kalinowsky, L; Heering, J; Kaiser, A; Ohrndorf, J; Proschak, E; Merk, D Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype. ACS Med Chem Lett 10:203-208 (2019) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-gamma
Synonyms:
NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha
Type:
PROTEIN
Mol. Mass.:
50878.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197216
Residue:
463
Sequence:
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
  
Inhibitor
Name:
BDBM50508799
Synonyms:
CHEMBL4519831
Type:
Small organic molecule
Emp. Form.:
C18H18O3
Mol. Mass.:
282.3337
SMILES:
OC(=O)Cc1ccc(COc2ccc3CCCc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: