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Target
Beta-1 adrenergic receptor
Ligand
BDBM50090153
Substrate
n/a
Meas. Tech.
ChEBML_37386
IC50
4800±n/a nM
Citation
 Ok, HO; Reigle, LB; Candelore, MR; Cascieri, MA; Colwell, LF; Deng, L; Feeney, WP; Forrest, MJ; Hom, GJ; MacIntyre, DE; Strader, CD; Tota, L; Wang, P; Wyvratt, MJ; Fisher, MH; Weber, AE Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists. Bioorg Med Chem Lett 10:1531-4 (2000) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50090153
Synonyms:
4-[2-((R)-2-Cyclopentyl-ethyl)-oxazol-5-yl]-N-{4-[2-(2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide | CHEMBL38254
Type:
Small organic molecule
Emp. Form.:
C31H36N4O4S
Mol. Mass.:
560.707
SMILES:
O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)-c2cnc(CCC3CCCC3)o2)cc1)c1cccnc1
Structure:
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