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Target
Urokinase-type plasminogen activator
Ligand
BDBM50099923
Substrate
n/a
Meas. Tech.
ChEBML_213135
Ki
47±n/a nM
Citation
 Subasinghe, NL; Illig, C; Hoffman, J; Rudolph, MJ; Wilson, KJ; Soll, R; Randle, T; Green, D; Lewandowski, F; Zhang, M; Bone, R; Spurlino, J; DesJarlais, R; Deckman, I; Molloy, CJ; Manthey, C; Zhou, Z; Sharp, C; Maguire, D; Crysler, C; Grasberger, B Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors. Bioorg Med Chem Lett 11:1379-82 (2001) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50099923
Synonyms:
CHEMBL29037 | N-{3-[2-(5-Carbamimidoyl-2-methylsulfanyl-thiophen-3-yl)-thiazol-4-yl]-phenyl}-4-fluoro-benzamide
Type:
Small organic molecule
Emp. Form.:
C22H17FN4OS3
Mol. Mass.:
468.59
SMILES:
CSc1sc(cc1-c1nc(cs1)-c1cccc(NC(=O)c2ccc(F)cc2)c1)C(N)=N
Structure:
Search PDB for entries with ligand similarity: