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Target
Glucagon receptor
Ligand
BDBM50104366
Substrate
n/a
Meas. Tech.
ChEBML_72873
IC50
6.5±n/a nM
Citation
 Chang, LL; Sidler, KL; Cascieri, MA; de Laszlo, S; Koch, G; Li, B; MacCoss, M; Mantlo, N; O'Keefe, S; Pang, M; Rolando, A; Hagmann, WK Substituted imidazoles as glucagon receptor antagonists. Bioorg Med Chem Lett 11:2549-53 (2001) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50104366
Synonyms:
4-[2-(4-Chloro-phenyl)-5-(2,4-dibutoxy-phenyl)-3H-imidazol-4-yl]-pyridine | CHEMBL86086
Type:
Small organic molecule
Emp. Form.:
C28H30ClN3O2
Mol. Mass.:
476.01
SMILES:
CCCCOc1ccc(-c2[nH]c(nc2-c2ccncc2)-c2ccc(Cl)cc2)c(OCCCC)c1
Structure:
Search PDB for entries with ligand similarity: