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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50104701
Substrate
n/a
Meas. Tech.
ChEMBL_214524 (CHEMBL819516)
IC50
>250000±n/a nM
Citation
 Sodeoka, M; Sampe, R; Kojima, S; Baba, Y; Usui, T; Ueda, K; Osada, H Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition. J Med Chem 44:3216-22 (2001) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50104701
Synonyms:
4-Hydroxy-5-hydroxymethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester | CHEMBL108970
Type:
Small organic molecule
Emp. Form.:
C16H9F17O6
Mol. Mass.:
620.2119
SMILES:
OCc1oc(O)c(C(=O)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c1O
Structure:
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