Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50137488
Substrate
n/a
Meas. Tech.
ChEBML_143777
IC50
1600±n/a nM
Citation
Beaulieu, PL; Bös, M; Bousquet, Y; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; LaPlante, S; Poupart, MA; Lefebvre, S; McKercher, G; Pellerin, C; Austel, V; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. Bioorg Med Chem Lett 14:119-24 (2003) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50137488
Synonyms:
1-Cyclohexyl-2-furan-3-yl-1H-benzoimidazole-5-carboxylic acid | 1-cyclohexyl-2-(furan-3-yl)-1H-benzo[d]imidazole-5-carboxylic acid | 1-cyclohexyl-2-furan-3-yl-1H-benzimidazole-5-carboxylic acid | CHEMBL175177
Type:
Small organic molecule
Emp. Form.:
C18H18N2O3
Mol. Mass.:
310.3471
SMILES:
OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccoc1