Reaction Details Report a problem with these data
Target
Cytochrome P450 2C19
Ligand
BDBM50572809
Substrate
n/a
Meas. Tech.
ChEMBL_2118303 (CHEMBL4827369)
IC50
>10000±n/a nM
Citation
Liang, J; Zbieg, JR; Blake, RA; Chang, JH; Daly, S; DiPasquale, AG; Friedman, LS; Gelzleichter, T; Gill, M; Giltnane, JM; Goodacre, S; Guan, J; Hartman, SJ; Ingalla, ER; Kategaya, L; Kiefer, JR; Kleinheinz, T; Labadie, SS; Lai, T; Li, J; Liao, J; Liu, Z; Mody, V; McLean, N; Metcalfe, C; Nannini, MA; Oeh, J; O'Rourke, MG; Ortwine, DF; Ran, Y; Ray, NC; Roussel, F; Sambrone, A; Sampath, D; Schutt, LK; Vinogradova, M; Wai, J; Wang, T; Wertz, IE; White, JR; Yeap, SK; Young, A; Zhang, B; Zheng, X; Zhou, W; Zhong, Y; Wang, X GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer. J Med Chem 64:11841-11856 (2021) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 2C19
Synonyms:
(R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C
Type:
Enzyme
Mol. Mass.:
55935.47
Organism:
Homo sapiens (Human)
Description:
P33261
Residue:
490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV