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Target
Vesicular acetylcholine transporter
Ligand
BDBM50183810
Substrate
n/a
Meas. Tech.
ChEMBL_354366 (CHEMBL870017)
IC50
>100±n/a nM
Citation
 Assaad, T; Mavel, S; Parsons, SM; Kruse, S; Galineau, L; Allouchi, H; Kassiou, M; Chalon, S; Guilloteau, D; Emond, P Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands. Bioorg Med Chem Lett 16:2654-7 (2006) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:
PROTEIN
Mol. Mass.:
56900.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507628
Residue:
532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  
Inhibitor
Name:
BDBM50183810
Synonyms:
1-benzyl-3-(4-phenylpiperazin-1-yl)piperidin-4-ol | CHEMBL209296
Type:
Small organic molecule
Emp. Form.:
C22H29N3O
Mol. Mass.:
351.4852
SMILES:
OC1CCN(Cc2ccccc2)CC1N1CCN(CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: