Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50189583
Substrate
n/a
Meas. Tech.
ChEMBL_368881 (CHEMBL865555)
Ki
4.4±n/a nM
Citation
 Dyck, B; Markison, S; Zhao, L; Tamiya, J; Grey, J; Rowbottom, MW; Zhang, M; Vickers, T; Sorensen, K; Norton, C; Wen, J; Heise, CE; Saunders, J; Conlon, P; Madan, A; Schwarz, D; Goodfellow, VS A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties. J Med Chem 49:3753-6 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50189583
Synonyms:
(S)-6-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-yl)-2-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyridazin-7(6H)-one | CHEMBL208845
Type:
Small organic molecule
Emp. Form.:
C24H22F3N5OS
Mol. Mass.:
485.525
SMILES:
CN(C)[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F
Structure:
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