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Target
TGF-beta receptor type-1
Ligand
BDBM50204834
Substrate
n/a
Meas. Tech.
ChEMBL_2274050
IC50
48±n/a nM
Citation
 Wang, H; Chen, M; Sang, X; You, X; Wang, Y; Paterson, IC; Hong, W; Yang, X Development of small molecule inhibitors targeting TGF-? ligand and receptor: Structures, mechanism, preclinical studies and clinical usage. Eur J Med Chem 191:0 (2020) [PubMed] 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50204834
Synonyms:
2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine | CHEMBL238125
Type:
Small organic molecule
Emp. Form.:
C17H10ClFN6
Mol. Mass.:
352.753
SMILES:
Fc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1
Structure:
Search PDB for entries with ligand similarity: