Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50225553
Substrate
n/a
Meas. Tech.
ChEMBL_451555 (CHEMBL901765)
IC50
7000±n/a nM
Citation
Furber, M; Alcaraz, L; Bent, JE; Beyerbach, A; Bowers, K; Braddock, M; Caffrey, MV; Cladingboel, D; Collington, J; Donald, DK; Fagura, M; Ince, F; Kinchin, EC; Laurent, C; Lawson, M; Luker, TJ; Mortimore, MM; Pimm, AD; Riley, RJ; Roberts, N; Robertson, M; Theaker, J; Thorne, PV; Weaver, R; Webborn, P; Willis, P Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors. J Med Chem 50:5882-5 (2007) [PubMed] Article
More Info.:
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Human
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
Inhibitor
Name:
BDBM50225553
Synonyms:
CHEMBL393754 | N-adamantan-1-ylmethyl-2-chloro-5-(9-oxa-3,7-diaza-bicyclo[3.3.1]nonane-3-carbonyl)-benzamide
Type:
Small organic molecule
Emp. Form.:
C25H32ClN3O3
Mol. Mass.:
457.993
SMILES:
Clc1ccc(cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)N1CC2CNCC(C1)O2 |w:29.33,25.28,TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17|