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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50231911
Substrate
n/a
Meas. Tech.
ChEMBL_462097 (CHEMBL944929)
Ki
1063±n/a nM
Citation
 Yoon, T; De Lombaert, S; Brodbeck, R; Gulianello, M; Chandrasekhar, J; Horvath, RF; Ge, P; Kershaw, MT; Krause, JE; Kehne, J; Hoffman, D; Doller, D; Hodgetts, KJ The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists. Bioorg Med Chem Lett 18:891-6 (2008) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50231911
Synonyms:
CHEMBL252301 | N-(2-(1H-imidazol-1-yl)ethyl)-1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N-propylisoquinolin-4-amine
Type:
Small organic molecule
Emp. Form.:
C27H32N4O
Mol. Mass.:
428.5692
SMILES:
CCCN(CCn1ccnc1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 |(25.87,-11.85,;27.21,-12.62,;27.22,-14.16,;28.56,-14.92,;29.89,-14.14,;29.88,-12.6,;31.21,-11.83,;31.36,-10.29,;32.86,-9.96,;33.64,-11.29,;32.61,-12.44,;28.56,-16.46,;27.24,-17.23,;25.9,-16.46,;27.24,-18.78,;28.57,-19.55,;28.57,-21.08,;27.24,-21.85,;25.9,-21.08,;27.24,-23.39,;28.57,-24.16,;28.57,-25.7,;29.91,-23.38,;29.9,-21.84,;31.23,-21.07,;32.57,-21.84,;29.91,-18.77,;31.23,-19.53,;32.58,-18.76,;32.57,-17.21,;31.23,-16.45,;29.9,-17.22,)|
Structure:
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