Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50231915
Substrate
n/a
Meas. Tech.
ChEMBL_462097 (CHEMBL944929)
Ki
49±n/a nM
Citation
 Yoon, T; De Lombaert, S; Brodbeck, R; Gulianello, M; Chandrasekhar, J; Horvath, RF; Ge, P; Kershaw, MT; Krause, JE; Kehne, J; Hoffman, D; Doller, D; Hodgetts, KJ The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists. Bioorg Med Chem Lett 18:891-6 (2008) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50231915
Synonyms:
1-(2-methoxy-4,6-dimethylphenyl)-N,N-dipropylisoquinolin-4-amine | CHEMBL253701
Type:
Small organic molecule
Emp. Form.:
C24H30N2O
Mol. Mass.:
362.5078
SMILES:
CCCN(CCC)c1cnc(-c2c(C)cc(C)cc2OC)c2ccccc12 |(-3.94,5.53,;-5.27,4.76,;-5.26,3.22,;-6.59,2.44,;-7.93,3.2,;-7.94,4.74,;-9.27,5.51,;-6.58,.9,;-7.91,.13,;-7.91,-1.42,;-6.58,-2.19,;-6.58,-3.72,;-7.91,-4.49,;-9.25,-3.72,;-7.91,-6.03,;-6.58,-6.8,;-6.57,-8.34,;-5.24,-6.02,;-5.25,-4.49,;-3.91,-3.71,;-2.58,-4.48,;-5.24,-1.41,;-3.92,-2.17,;-2.57,-1.4,;-2.58,.15,;-3.92,.91,;-5.24,.14,)|
Structure:
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