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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50231918
Substrate
n/a
Meas. Tech.
ChEMBL_462097 (CHEMBL944929)
Ki
215±n/a nM
Citation
 Yoon, T; De Lombaert, S; Brodbeck, R; Gulianello, M; Chandrasekhar, J; Horvath, RF; Ge, P; Kershaw, MT; Krause, JE; Kehne, J; Hoffman, D; Doller, D; Hodgetts, KJ The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists. Bioorg Med Chem Lett 18:891-6 (2008) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50231918
Synonyms:
1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N-propyl-N-(2-(pyrrolidin-1-yl)ethyl)isoquinolin-4-amine | CHEMBL404558
Type:
Small organic molecule
Emp. Form.:
C28H37N3O
Mol. Mass.:
431.6129
SMILES:
CCCN(CCN1CCCC1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 |(14.6,-12.37,;15.93,-13.14,;15.94,-14.68,;17.28,-15.44,;18.61,-14.67,;18.6,-13.13,;19.93,-12.35,;21.34,-12.96,;22.36,-11.81,;21.59,-10.48,;20.08,-10.81,;17.29,-16.98,;15.96,-17.75,;14.63,-16.98,;15.96,-19.3,;17.29,-20.07,;17.29,-21.6,;15.96,-22.37,;14.62,-21.6,;15.96,-23.91,;17.29,-24.68,;17.3,-26.22,;18.63,-23.9,;18.62,-22.37,;19.96,-21.59,;21.29,-22.36,;18.63,-19.29,;19.95,-20.05,;21.3,-19.28,;21.29,-17.73,;19.95,-16.97,;18.63,-17.75,)|
Structure:
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