Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50276672
Substrate
n/a
Meas. Tech.
ChEMBL_540889 (CHEMBL1026563)
IC50
41±n/a nM
Citation
Pryde, DC; Corless, M; Fenwick, DR; Mason, HJ; Stammen, BC; Stephenson, PT; Ellis, D; Bachelor, D; Gordon, D; Barber, CG; Wood, A; Middleton, DS; Blakemore, DC; Parsons, GC; Eastwood, R; Platts, MY; Statham, K; Paradowski, KA; Burt, C; Klute, W The design and discovery of novel amide CCR5 antagonists. Bioorg Med Chem Lett 19:1084-8 (2009) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Inhibitor
Name:
BDBM50276672
Synonyms:
(4-(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl)piperidin-1-yl)(2,4-dimethylpyridin-3-yl)methanone | CHEMBL514749
Type:
Small organic molecule
Emp. Form.:
C32H38N4O
Mol. Mass.:
494.6703
SMILES:
Cc1ccnc(C)c1C(=O)N1CCC(CC1)N1C2CCC1CN(C2)C(c1ccccc1)c1ccccc1