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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50258205
Substrate
n/a
Meas. Tech.
ChEMBL_566056 (CHEMBL954321)
IC50
24±n/a nM
Citation
 Hauze, DB; Chengalvala, MV; Cottom, JE; Feingold, IB; Garrick, L; Green, DM; Huselton, C; Kao, W; Kees, K; Lundquist, JT; Mann, CW; Mehlmann, JF; Rogers, JF; Shanno, L; Wrobel, J; Pelletier, JC Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template. Bioorg Med Chem Lett 19:1986-90 (2009) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50258205
Synonyms:
2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole | CHEMBL521674
Type:
Small organic molecule
Emp. Form.:
C28H36N6
Mol. Mass.:
456.6256
SMILES:
CCn1cnc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)c1C
Structure:
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