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Target
Type-1 angiotensin II receptor
Ligand
BDBM82433
Substrate
n/a
Meas. Tech.
ChEBML_36629
IC50
1.7±n/a nM
Citation
 Chang, LL; Ashton, WT; Flanagan, KL; Rivero, RA; Chen, TB; O'Malley, SS; Zingaro, GJ; Kivlighn, SD; Siegl, PK; Lotti, VJ; Chang, RS; Greenlee, WJ Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes Bioorg Med Chem Lett 4:2787-2792 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM82433
Synonyms:
CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[[2-propyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3,4-dihydro-4-oxoquinazolin]-6-yl]benzamide
Type:
Small organic molecule
Emp. Form.:
C37H37N7O2
Mol. Mass.:
611.7354
SMILES:
CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: