Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50288456
Substrate
n/a
Meas. Tech.
ChEBML_208327
Ki
1800±n/a nM
Citation
Greco, MN; Powell, ET; Hecker, LR; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Ganesh, V; Tulinsky, A; Maryanoff, BE Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif Bioorg Med Chem Lett 6:2947-2952 (1996) Article
More Info.:
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Inhibitor
Name:
BDBM50288456
Synonyms:
CHEMBL430844 | N-[3-((5S,17R,19aR)-5-Benzyl-4,7,15,16,19-pentaoxo-icosahydro-3a,6,14,18-tetraaza-cyclopentacyclooctadecen-17-yl)-propyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C28H41N7O5
Mol. Mass.:
555.669
SMILES:
NC(=N)NCCC[C@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCCCNC(=O)C1=O