Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50288456
Substrate
n/a
Meas. Tech.
ChEBML_212504
Ki
280±n/a nM
Citation
 Greco, MN; Powell, ET; Hecker, LR; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Ganesh, V; Tulinsky, A; Maryanoff, BE Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif Bioorg Med Chem Lett 6:2947-2952 (1996)    Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50288456
Synonyms:
CHEMBL430844 | N-[3-((5S,17R,19aR)-5-Benzyl-4,7,15,16,19-pentaoxo-icosahydro-3a,6,14,18-tetraaza-cyclopentacyclooctadecen-17-yl)-propyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C28H41N7O5
Mol. Mass.:
555.669
SMILES:
NC(=N)NCCC[C@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCCCNC(=O)C1=O
Structure:
Search PDB for entries with ligand similarity: