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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50152761
Substrate
n/a
Meas. Tech.
ChEMBL_306402 (CHEMBL828743)
IC50
1366±n/a nM
Citation
 Jin, Q; Nie, H; McCleland, BW; Widdowson, KL; Palovich, MR; Elliott, JD; Goodman, RM; Burman, M; Sarau, HM; Ward, KW; Nord, M; Orr, BM; Gorycki, PD; Busch-Petersen, J Discovery of potent and orally bioavailable N,N'-diarylurea antagonists for the CXCR2 chemokine receptor. Bioorg Med Chem Lett 14:4375-8 (2004) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50152761
Synonyms:
3-[3-(2-Bromo-phenyl)-ureido]-6-chloro-2-hydroxy-benzenesulfonamide | CHEMBL359670
Type:
Small organic molecule
Emp. Form.:
C13H11BrClN3O4S
Mol. Mass.:
420.666
SMILES:
NS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Br)c1O
Structure:
Search PDB for entries with ligand similarity: