Reaction Details Report a problem with these data
Target
Caspase-8
Ligand
BDBM50171130
Substrate
n/a
Meas. Tech.
ChEMBL_321471 (CHEMBL880412)
IC50
>10000±n/a nM
Citation
Oppong, KA; Ellis, CD; Laufersweiler, MC; O'Neil, SV; Wang, Y; Soper, DL; Baize, MW; Wos, JA; De, B; Bosch, GK; Fancher, AN; Lu, W; Suchanek, MK; Wang, RL; Demuth, TP Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis. Bioorg Med Chem Lett 15:4291-4 (2005) [PubMed] Article
More Info.:
Target
Name:
Caspase-8
Synonyms:
Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog
Type:
Enzyme
Mol. Mass.:
55373.89
Organism:
Homo sapiens (Human)
Description:
Q14790
Residue:
479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Inhibitor
Name:
BDBM50171130
Synonyms:
CHEMBL372509 | Naphthalene-2-carboxylic acid [(S)-1-[((S)-2-hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-5-(2-methoxy-benzoyl)-2-oxo-[1,5]diazocan-3-yl]-amide
Type:
Small organic molecule
Emp. Form.:
C31H32N4O8
Mol. Mass.:
588.6078
SMILES:
COc1ccccc1C(=O)N1CCCN(CC(=O)N[C@H]2CC(=O)OC2O)C(=O)[C@H](C1)NC(=O)c1ccc2ccccc2c1