Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM50191906
Substrate
n/a
Meas. Tech.
ChEMBL_399982 (CHEMBL910313)
IC50
150±n/a nM
Citation
Ellis, CD; Oppong, KA; Laufersweiler, MC; O'Neil, SV; Soper, DL; Wang, Y; Wos, JA; Fancher, AN; Lu, W; Suchanek, MK; Wang, RL; De, B; Demuth, TP Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors. Bioorg Med Chem Lett 16:4728-32 (2006) [PubMed] Article
More Info.:
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Inhibitor
Name:
BDBM50191906
Synonyms:
CHEMBL215512 | N-((R)-4-(2-((S)-2-hydroxy-5-oxo-tetrahydrofuran-3ylamino)-2-oxoethyl)-1,1-dioxido-5-oxo-1,4-thiazepan-6-yl)-2-naphthamide
Type:
Small organic molecule
Emp. Form.:
C22H23N3O8S
Mol. Mass.:
489.498
SMILES:
OC1OC(=O)C[C@@H]1NC(=O)CN1CCS(=O)(=O)C[C@H](NC(=O)c2ccc3ccccc3c2)C1=O