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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50272698
Substrate
n/a
Meas. Tech.
ChEMBL_510097 (CHEMBL998751)
Ki
1150±n/a nM
Citation
 Yoon, T; De Lombaert, S; Brodbeck, R; Gulianello, M; Krause, JE; Hutchison, A; Horvath, RF; Ge, P; Kehne, J; Hoffman, D; Chandrasekhar, J; Doller, D; Hodgetts, KJ 2-Arylpyrimidines: novel CRF-1 receptor antagonists. Bioorg Med Chem Lett 18:4486-90 (2008) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50272698
Synonyms:
1-(5-(dipropylamino)-6-methoxy-2-(2-methoxy-4,6-dimethylphenyl)pyrimidin-4-yl)propan-2-ol | CHEMBL496269
Type:
Small organic molecule
Emp. Form.:
C23H35N3O3
Mol. Mass.:
401.5423
SMILES:
CCCN(CCC)c1c(CC(C)O)nc(nc1OC)-c1c(C)cc(C)cc1OC
Structure:
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