Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM52230
Substrate
n/a
Meas. Tech.
ChEMBL_661807 (CHEMBL1252123)
IC50
64200±n/a nM
Citation
 El Turk, F; Fauvet, B; Ouertatani-Sakouhi, H; Lugari, A; Betzi, S; Roche, P; Morelli, X; Lashuel, HA An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem 18:5425-40 (2010) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM52230
Synonyms:
(Z)-2-(1,3-benzoxazol-2-yl)-3-(2-pyridinylamino)-2-propenal | (Z)-2-(1,3-benzoxazol-2-yl)-3-(2-pyridylamino)acrolein | (Z)-2-(1,3-benzoxazol-2-yl)-3-(pyridin-2-ylamino)prop-2-enal | 2-Benzooxazol-2-yl-3-(pyridin-2-ylamino)-propenal | MLS000525515 | SMR000115989 | cid_2249389
Type:
Small organic molecule
Emp. Form.:
C15H11N3O2
Mol. Mass.:
265.2667
SMILES:
O=CC(C=Nc1ccccn1)c1nc2ccccc2o1 |w:4.4|
Structure:
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