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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50300798
Substrate
n/a
Meas. Tech.
ChEMBL_1475131 (CHEMBL3424809)
Ki
9330±n/a nM
Citation
 Beinat, C; Reekie, T; Banister, SD; O'Brien-Brown, J; Xie, T; Olson, TT; Xiao, Y; Harvey, A; O'Connor, S; Coles, C; Grishin, A; Kolesik, P; Tsanaktsidis, J; Kassiou, M Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities ata7 nAChRs through incorporation of known structural motifs. Eur J Med Chem 95:277-301 (2015) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50300798
Synonyms:
5-(4-Methylpiperazin-1-yl)pentanoic acid(4-pyridin-3-ylphenyl)amide | CHEMBL568464
Type:
Small organic molecule
Emp. Form.:
C21H28N4O
Mol. Mass.:
352.4732
SMILES:
CN1CCN(CCCCC(=O)Nc2ccc(cc2)-c2cccnc2)CC1
Structure:
Search PDB for entries with ligand similarity: