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Target
Scavenger receptor class B member 1
Ligand
BDBM50088265
Substrate
n/a
Meas. Tech.
ChEMBL_1476710 (CHEMBL3429061)
IC50
1600±n/a nM
Citation
 Dockendorff, C; Faloon, PW; Germain, A; Yu, M; Youngsaye, W; Nag, PP; Bennion, M; Penman, M; Nieland, TJ; Dandapani, S; Perez, JR; Munoz, B; Palmer, MA; Schreiber, SL; Krieger, M Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2594-8 (2015) [PubMed]  Article 
Target
Name:
Scavenger receptor class B member 1
Synonyms:
SCRB1_MOUSE | SR-BI | Scarb1 | Scavenger receptor class B member 1 | Srb1
Type:
PROTEIN
Mol. Mass.:
56761.39
Organism:
Mus musculus
Description:
ChEMBL_103999
Residue:
509
Sequence:
MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL
  
Inhibitor
Name:
BDBM50088265
Synonyms:
CHEMBL3427491
Type:
Small organic molecule
Emp. Form.:
C26H38N6O4
Mol. Mass.:
498.6177
SMILES:
COc1ccc(cc1OC)-c1nnn(CC(=O)N(CC2CCCCC2)C(C)C(=O)NC2CCCC2)n1
Structure:
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