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Target
Sodium channel protein type 1 subunit alpha [1489-1708]
Ligand
BDBM50117271
Substrate
n/a
Meas. Tech.
ChEMBL_1525517 (CHEMBL3636870)
IC50
21000±n/a nM
Citation
Suzuki, S; Kuroda, T; Kimoto, H; Domon, Y; Kubota, K; Kitano, Y; Yokoyama, T; Shimizugawa, A; Sugita, R; Koishi, R; Asano, D; Tamaki, K; Shinozuka, T; Kobayashi, H Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors. Bioorg Med Chem Lett 25:5419-23 (2015) [PubMed] Article
More Info.:
Target
Name:
Sodium channel protein type 1 subunit alpha [1489-1708]
Synonyms:
SCN1A_MOUSE | Scn1a | Voltage-gated sodium channel alpha subunit Nav1.1
Type:
PROTEIN
Mol. Mass.:
25514.04
Organism:
Mus musculus
Description:
ChEMBL_109872
Residue:
220
Sequence:
QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFE
Inhibitor
Name:
BDBM50117271
Synonyms:
1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-dimethylphenoxy)propan-2-amine | 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine | 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine(mexiletine) | CHEMBL558 | MEXILETINE | Mexitil
Type:
Small organic molecule
Emp. Form.:
C11H17NO
Mol. Mass.:
179.2588
SMILES:
CC(N)COc1c(C)cccc1C