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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50187698
Substrate
n/a
Meas. Tech.
ChEMBL_1591271 (CHEMBL3829804)
EC50
5700±n/a nM
Citation
 Gomtsyan, A; Schmidt, RG; Bayburt, EK; Gfesser, GA; Voight, EA; Daanen, JF; Schmidt, DL; Cowart, MD; Liu, H; Altenbach, RJ; Kort, ME; Clapham, B; Cox, PB; Shrestha, A; Henry, R; Whittern, DN; Reilly, RM; Puttfarcken, PS; Brederson, JD; Song, P; Li, B; Huang, SM; McDonald, HA; Neelands, TR; McGaraughty, SP; Gauvin, DM; Joshi, SK; Banfor, PN; Segreti, JA; Shebley, M; Faltynek, CR; Dart, MJ; Kym, PR Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem 59:4926-47 (2016) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50187698
Synonyms:
CHEMBL3827928
Type:
Small organic molecule
Emp. Form.:
C17H14F5NO2
Mol. Mass.:
359.2906
SMILES:
O[C@H](c1ccccn1)C1(CC(F)(F)C1)c1ccc(OC(F)(F)F)cc1 |r|
Structure:
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