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Target
Tryptase delta
Ligand
BDBM50217815
Substrate
n/a
Meas. Tech.
ChEMBL_210701 (CHEMBL817298)
IC50
6.0±n/a nM
Citation
 Slusarchyk, WA; Bolton, SA; Hartl, KS; Huang, MH; Jacobs, G; Meng, W; Ogletree, ML; Pi, Z; Schumacher, WA; Seiler, SM; Sutton, JC; Treuner, U; Zahler, R; Zhao, G; Bisacchi, GS Synthesis of potent and highly selective inhibitors of human tryptase. Bioorg Med Chem Lett 12:3235-8 (2002) [PubMed]  Article 
Target
Name:
Tryptase delta
Synonyms:
Delta-tryptase | HmMCP-3-like tryptase III | Mast cell mMCP-7-like | TPSD1 | TRYD_HUMAN | Tryptase delta | Tryptase-3
Type:
PROTEIN
Mol. Mass.:
26578.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104777
Residue:
242
Sequence:
MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGPYWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPYPLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVNGT
  
Inhibitor
Name:
BDBM50217815
Synonyms:
CHEMBL113591
Type:
Small organic molecule
Emp. Form.:
C28H41N7O5
Mol. Mass.:
555.669
SMILES:
CN(CCCCc1ccccc1)C(=O)N1CCN(CC1)C(=O)N1[C@@H]([C@@H](CC2CCCN(C2)C(N)=N)C1=O)C(O)=O
Structure:
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