Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM134278
Substrate
n/a
Meas. Tech.
Inhibitory Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Muto, T; Tanaka, T; Futamura, J; Imajo, S; Sugawara, H Seven-membered ring compound and pharmaceutical use therefor US Patent  US8846660 Publication Date 9/30/2014 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM134278
Synonyms:
US8846660, 96
Type:
Small organic molecule
Emp. Form.:
C27H30ClN5O7
Mol. Mass.:
572.009
SMILES:
CCC[C@@H](NC(=O)N1CC2=NOCC(=O)N2CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1 |r,t:9|
Structure:
Search PDB for entries with ligand similarity: