Compile Data Set for Download or QSAR
Report error Found 658 of affinity data for UniProtKB/TrEMBL: P06730
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  0.0160nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525089(CHEMBL4464315)
Affinity DataKd:  0.0460nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to purified elF4EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Ser 209 phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597686(CHEMBL5183975)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525091(CHEMBL4447089)
Affinity DataKd:  5.20nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525087(CHEMBL4577429)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of eIF4E phosphorylation at ser209 residue in human HeLa cells incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50565475(CHEMBL4777401)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597684(CHEMBL5203720)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597685(CHEMBL5181488)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50386777(CHEMBL2046918)
Affinity DataIC50: 16nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597682(CHEMBL5206647)
Affinity DataIC50: 16nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  17nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451155(US10676499, Example 49)
Affinity DataKi:  20nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597674(CHEMBL5187414)
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451152(US10676499, Example 41)
Affinity DataKd:  20nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597673(CHEMBL5175341)
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597675(CHEMBL5184155)
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  21nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50565475(CHEMBL4777401)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597676(CHEMBL5196084)
Affinity DataIC50: 25nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597679(CHEMBL5195407)
Affinity DataIC50: 25nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50316302(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKi:  28nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451148(US10676499, Example 29)
Affinity DataKi:  30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525090(CHEMBL4558213)
Affinity DataKd:  30nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451145(US10676499, Example 17)
Affinity DataKi:  30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451159(US10676499, Example 57)
Affinity DataKi:  30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451149(US10676499, Example 32)
Affinity DataKd:  30nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597683(CHEMBL5171562)
Affinity DataIC50: 32nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597672(CHEMBL5195560)
Affinity DataIC50: 32nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597687(CHEMBL5180948)
Affinity DataIC50: 32nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597671(CHEMBL5186068)
Affinity DataIC50: 40nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597680(CHEMBL5205835)
Affinity DataIC50: 40nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451158(US10676499, Example 55)
Affinity DataKi:  40nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50386762(CHEMBL2046906)
Affinity DataIC50: 41nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525089(CHEMBL4464315)
Affinity DataKd:  48nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM451147(US10676499, Example 26)
Affinity DataKi:  50nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597678(CHEMBL5183411)
Affinity DataIC50: 50nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50386774(CHEMBL2046915)
Affinity DataIC50: 51nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50639445(CHEMBL5561277)
Affinity DataIC50: 53nMAssay Description:Inhibition of eIF4E phosphorylation at ser209 residue in human HeLa cells incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50386769(CHEMBL2046910)
Affinity DataIC50: 56nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50386766(CHEMBL2046905)
Affinity DataIC50: 59nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50639443(CHEMBL5561300)
Affinity DataIC50: 72nMAssay Description:Inhibition of eIF4E phosphorylation at ser209 residue in human HeLa cells incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50597681(CHEMBL5197975)
Affinity DataIC50: 79nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50639449(CHEMBL5559028)
Affinity DataIC50: 91nMAssay Description:Inhibition of eIF4E phosphorylation at ser209 residue in human HeLa cells incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
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