BDBM50258424 CHEMBL494221::trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-ylamino)cyclohexanol

SMILES: O[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2n1

InChI Key: InChIKey=DJIOCMRPQBSLOC-UHFFFAOYSA-N

Data: 18 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50258424   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C theta type (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 4 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 10 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 7 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ITK/TSK (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK1 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 1 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 8 (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase SYK (Human)	BDBM50258424 (trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]tria...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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