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Found 135 with Last Name = 'beight' and Initial = 'dw'
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044868(7-(1-Carboxy-3-phenyl-propylamino)-6-oxo-1,2,3,4,6...)
Affinity DataKi:  0.00400nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287694(3-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287702((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287689(CHEMBL304233 | [(2-Mercaptomethyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287700((S)-3-(4-Hydroxy-phenyl)-2-[(2-mercaptomethyl-1,2,...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287699(4-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287690(7-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50024096(((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287696((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  2nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044867(7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-octahydro...)
Affinity DataKi:  2nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50024096(((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  2nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044869(7-(2-Mercapto-acetylamino)-6-oxo-1,2,3,4,6,7,8,12b...)
Affinity DataKi:  2nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287695((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  4nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044869(7-(2-Mercapto-acetylamino)-6-oxo-1,2,3,4,6,7,8,12b...)
Affinity DataKi:  5nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287701((4S,7S)-7-(2-Mercapto-acetylamino)-6-oxo-1,2,3,4,6...)
Affinity DataKi:  5nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044867(7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-octahydro...)
Affinity DataKi: >7nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287693((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  7nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287692(CHEMBL431957 | [(2-Mercaptomethyl-indane-2-carbony...)
Affinity DataKi:  10nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287691(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalene-2-...)
Affinity DataKi:  14nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287698((4S,7R)-7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-o...)
Affinity DataKi:  45nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044867(7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-octahydro...)
Affinity DataKi:  45nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50024096(((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  130nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50287697((4S,7S)-7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-o...)
Affinity DataKi: >300nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044867(7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-octahydro...)
Affinity DataKi: >300nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044868(7-(1-Carboxy-3-phenyl-propylamino)-6-oxo-1,2,3,4,6...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161301(2-[4-(2-Benzenesulfonylamino-2-oxo-ethoxy)-1-benzy...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161305((3-Aminooxalyl-1-cyclohexylmethyl-2-methyl-2,3-dih...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161293((3-Aminooxalyl-1-benzyl-2-methyl-1,6,7,8-tetrahydr...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50:  6.80nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161299((3-Aminooxalyl-1-benzyl-2-ethyl-1,6,7,8-tetrahydro...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161301(2-[4-(2-Benzenesulfonylamino-2-oxo-ethoxy)-1-benzy...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  7.10nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161308(CHEMBL179118 | [3-Aminooxalyl-1-(2-fluoro-benzyl)-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161298((3-Aminooxalyl-1-benzyl-2-methyl-2,3,6,7,8,9-hexah...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161294(CHEMBL179966 | [3-Aminooxalyl-1-(3-fluoro-benzyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161293((3-Aminooxalyl-1-benzyl-2-methyl-1,6,7,8-tetrahydr...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161296((3-Aminooxalyl-1-benzyl-2-ethyl-2,3,6,7,8,9-hexahy...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161305((3-Aminooxalyl-1-cyclohexylmethyl-2-methyl-2,3-dih...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161299((3-Aminooxalyl-1-benzyl-2-ethyl-1,6,7,8-tetrahydro...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161298((3-Aminooxalyl-1-benzyl-2-methyl-2,3,6,7,8,9-hexah...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against human nonpancreatic secretory phospholipase A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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