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Target
Neutrophil elastase
Ligand
BDBM50349391
Substrate
n/a
Meas. Tech.
ChEMBL_759348 (CHEMBL1809811)
IC50
260±n/a nM
Citation
 Crocetti, L; Giovannoni, MP; Schepetkin, IA; Quinn, MT; Khlebnikov, AI; Cilibrizzi, A; Piaz, VD; Graziano, A; Vergelli, C Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Bioorg Med Chem 19:4460-72 (2011) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50349391
Synonyms:
CHEMBL1808528
Type:
Small organic molecule
Emp. Form.:
C17H11F3N2O3
Mol. Mass.:
348.276
SMILES:
FC(F)(F)COC(=O)c1nn(C(=O)c2ccccc2)c2ccccc12
Structure:
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