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Target
cGMP-specific 3',5'-cyclic phosphodiesterase
Ligand
BDBM50207127
Substrate
n/a
Meas. Tech.
ChEMBL_454819 (CHEMBL886847)
IC50
8±n/a nM
Citation
 Arnold, NJ; Arnold, R; Beer, D; Bhalay, G; Collingwood, SP; Craig, S; Devereux, N; Dodds, M; Dunstan, AR; Fairhurst, RA; Farr, D; Fullerton, JD; Glen, A; Gomez, S; Haberthuer, S; Hatto, JD; Howes, C; Jones, D; Keller, TH; Leuenberger, B; Moser, HE; Muller, I; Naef, R; Nicklin, PA; Sandham, DA; Turner, KL; Tweed, MF; Watson, SJ; Zurini, M Potent and selective xanthine-based inhibitors of phosphodiesterase 5. Bioorg Med Chem Lett 17:2376-9 (2007) [PubMed]  Article 
Target
Name:
cGMP-specific 3',5'-cyclic phosphodiesterase
Synonyms:
3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase
Type:
Protein
Mol. Mass.:
99975.83
Organism:
Homo sapiens (Human)
Description:
O76074
Residue:
875
Sequence:
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
  
Inhibitor
Name:
BDBM50207127
Synonyms:
8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl-3-neopentyl-1H-purine-2,6(3H,7H)-dione | CHEMBL245841
Type:
Small organic molecule
Emp. Form.:
C23H27N5O4
Mol. Mass.:
437.4916
SMILES:
COc1cc2cncc(Cc3nc4n(CC(C)(C)C)c(=O)n(C)c(=O)c4[nH]3)c2cc1OC
Structure:
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