BDBM4445 4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile::4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile::6,7-dialkoxyquinoline-3-carbonitrile deriv. 8::CHEMBL111038

SMILES COc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1OC

InChI Key InChIKey=CQKFTSMPIIYOBX-UHFFFAOYSA-N

Data  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 4445   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Affinity DataIC50:  190nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Affinity DataIC50:  190nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Affinity DataIC50:  191nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Affinity DataIC50:  90nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Affinity DataIC50:  130nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human EGFR kinase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed