BindingDB PrimarySearch_ki

Found 203 with Last Name = 'soriano' and Initial = 'm'

Beta-2 adrenergic receptor(Homo sapiens (Human))
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL

PNG

BDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)

Ki: 501nMAssay Description:Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Beta-2 adrenergic receptor(Homo sapiens (Human))
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL

PNG

BDBM50361247(ALBUTEROL | LEVOSALBUTAMOL | Levalbuterol | Levoli...)

Ki: 3.80E+3nMAssay Description:Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM boric acidMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Beta-2 adrenergic receptor(Homo sapiens (Human))
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL

PNG

BDBM50026626(CHEMBL2068576)

Ki: 3.89E+3nMAssay Description:Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Beta-2 adrenergic receptor(Homo sapiens (Human))
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL

PNG

BDBM50361247(ALBUTEROL | LEVOSALBUTAMOL | Levalbuterol | Levoli...)

Ki: 4.68E+3nMAssay Description:Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM phenylboronic acidMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Beta-2 adrenergic receptor(Homo sapiens (Human))
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL

PNG

BDBM50361247(ALBUTEROL | LEVOSALBUTAMOL | Levalbuterol | Levoli...)

Ki: 5.62E+3nMAssay Description:Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Beta-2 adrenergic receptor(Homo sapiens (Human))
Instituto Polit£Cnico Nacional (Ipn)

Curated by ChEMBL

PNG

BDBM50026625(CHEMBL2068577)

Ki: 6.61E+3nMAssay Description:Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530536(CHEMBL4580996 | US11174268, Example 336)

IC50: 13nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530536(CHEMBL4580996 | US11174268, Example 336)

IC50: 13nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530541(CHEMBL4468899 | US11174268, Example 38)

IC50: 20nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530541(CHEMBL4468899 | US11174268, Example 38)

IC50: 20nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530533(CHEMBL4435054 | US11174268, Example 185)

IC50: 20nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530533(CHEMBL4435054 | US11174268, Example 185)

IC50: 20nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530557(CHEMBL4444000 | US11174268, Example 246)

IC50: 30nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530557(CHEMBL4444000 | US11174268, Example 246)

IC50: 30nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530539(CHEMBL4460028 | US11174268, Example 300)

IC50: 31nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530539(CHEMBL4460028 | US11174268, Example 300)

IC50: 31nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530547(CHEMBL4544968 | US11174268, Example 113)

IC50: 40nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530546(CHEMBL4530743 | US11174268, Example 52)

IC50: 40nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530546(CHEMBL4530743 | US11174268, Example 52)

IC50: 40nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530547(CHEMBL4544968 | US11174268, Example 113)

IC50: 40nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530537(CHEMBL4471825)

IC50: 40nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530537(CHEMBL4471825)

IC50: 40nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530535(CHEMBL4466858 | US11174268, Example 205)

IC50: 47nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530535(CHEMBL4466858 | US11174268, Example 205)

IC50: 47nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530538(CHEMBL4580815)

IC50: 50nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530538(CHEMBL4580815)

IC50: 50nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530539(CHEMBL4460028 | US11174268, Example 300)

IC50: 60nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530539(CHEMBL4460028 | US11174268, Example 300)

IC50: 60nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530535(CHEMBL4466858 | US11174268, Example 205)

IC50: 60nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530535(CHEMBL4466858 | US11174268, Example 205)

IC50: 60nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530533(CHEMBL4435054 | US11174268, Example 185)

IC50: 66nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530533(CHEMBL4435054 | US11174268, Example 185)

IC50: 66nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530550(CHEMBL4529272 | US11174268, Example 238)

IC50: 70nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530550(CHEMBL4529272 | US11174268, Example 238)

IC50: 70nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530554(CHEMBL4457973 | US11174268, Example 59)

IC50: 80nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530554(CHEMBL4457973 | US11174268, Example 59)

IC50: 80nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530553(CHEMBL4462046)

IC50: 100nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530553(CHEMBL4462046)

IC50: 100nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530534(CHEMBL4445144 | US11174268, Example 331)

IC50: 110nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530534(CHEMBL4445144 | US11174268, Example 331)

IC50: 110nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530536(CHEMBL4580996 | US11174268, Example 336)

IC50: 119nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530536(CHEMBL4580996 | US11174268, Example 336)

IC50: 119nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530542(CHEMBL4558113 | US11174268, Example 255)

IC50: 120nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530542(CHEMBL4558113 | US11174268, Example 255)

IC50: 120nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530537(CHEMBL4471825)

IC50: 125nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

Sodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530537(CHEMBL4471825)

IC50: 125nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530544(CHEMBL4474960 | US11174268, Example 76)

IC50: 130nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530544(CHEMBL4474960 | US11174268, Example 76)

IC50: 130nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530558(CHEMBL4459170 | US11174268, Example 230)

IC50: 140nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Sodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50530558(CHEMBL4459170 | US11174268, Example 230)

IC50: 140nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Displayed 1 to 50 (of 203 total ) | Next | Last >>

Filter my 203 hits

Targets 13▿
- Sodium channel protein type 8 subunit alpha/subunit beta-1 54
- Beta-2 adrenergic receptor 33
- Nuclear receptor subfamily 1 group I member 2 30
- Sodium channel protein type 1 subunit alpha/subunit beta-1 14
- Sodium channel protein type 5 subunit alpha/subunit beta-1 12
- Sodium channel protein type 9 subunit alpha/subunit beta-1 10
- Cytochrome P450 2C9 10
- Sodium channel subunit beta-1 10
- Cytochrome P450 1A2 6
- Cytochrome P450 2C19 6
- Cytochrome P450 2D6 6
- Potassium voltage-gated channel subfamily H member 2 6
- Cytochrome P450 3A4 6
- ...
Publications 4▿
- J Med Chem 62: 9618-9641 (2019) 170
- Eur J Med Chem 44: 2840-6 (2009) 14
- Bioorg Med Chem 20: 933-41 (2012) 13
- Bioorg Med Chem Lett 25: 820-5 (2015) 6
Institutions 2▿
- Xenon Pharmaceuticals 170
- Instituto Polit£Cnico Nacional (Ipn) 33
Affinity: 0.072 to 6.5E+4 nM▿
- Ki 6
- IC50 140
- Kd 16
- EC50 41
- Affinity ≤ nM
Xtal structures: 5
Docked structures: 0
Catalog Cmpds: 11