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Found 1444 with Last Name = 'janusz' and Initial = 'mj'
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataKi:  0.0380nMAssay Description:Inhibition of collagenase (Matrix metalloprotease-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataKi:  0.0830nMAssay Description:Inhibition of gelatinase-A (Matrix metalloprotease-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035500((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035489((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-sulfonyl)-b...)
Affinity DataKi:  2nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035528(Acetic acid (E)-2-[((S)-1-{(S)-2-[4-(4-chloro-benz...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035500((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  3nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50281590(CHEMBL150384 | N-(1-Benzyl-3,3,3-trifluoro-2-oxo-p...)
Affinity DataKi:  4nMAssay Description:The compound was tested for its potency to inhibit human neutrophil elastase activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035488((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  7nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 100 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of collagenase-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035498((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  12nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035498((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  12nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50281589(5N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)-1-[3-met...)
Affinity DataKi:  16nMAssay Description:The compound was tested for its potency to inhibit human neutrophil elastase activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035535(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065147((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  18nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035492((S)-1-{(S)-3-Methyl-2-[4-(2-methyl-4-morpholin-4-y...)
Affinity DataKi:  19nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  20nMAssay Description:Inhibition of gelatinase-A (Matrix metalloprotease-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065158((R)-4-Benzyloxy-1-{(S)-3-methyl-2-[4-(morpholine-4...)
Affinity DataKi:  20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035494(CHEMBL429359 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  21nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035485((S)-1-((S)-3-Methyl-2-{4-[4-(morpholine-4-carbonyl...)
Affinity DataKi:  24nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035531(CHEMBL74332 | Isobutyric acid (E)-3-methyl-2-[((S)...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035530(CHEMBL74651 | Propionic acid (E)-3-methyl-2-[((S)-...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035532(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  25nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035487(CHEMBL140639 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  28nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035502((S)-1-[(S)-3-Methyl-2-(3-pyridin-3-yl-propionylami...)
Affinity DataKi:  29nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  33nMAssay Description:Inhibition of collagenase-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065157((R)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  34nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035505(CHEMBL140763 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  39nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065161(Acetic acid 1-{(S)-3-methyl-2-[4-(morpholine-4-car...)
Affinity DataKi:  40nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  43nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035497(CHEMBL141423 | Morpholine-4-carboxylic acid (4-{(S...)
Affinity DataKi:  43nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035486((S)-1-{(S)-3-Methyl-2-[3-methyl-2-(morpholine-4-ca...)
Affinity DataKi:  44nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataKi:  54nMAssay Description:Inhibition of matrilysin (Matrix metalloprotease-7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50281591(CHEMBL345477 | {(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4-p...)
Affinity DataKi:  55nMAssay Description:The compound was tested for its potency to inhibit human neutrophil elastase activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035501((S)-1-{(S)-3-Methyl-2-[(tetrahydro-pyran-4-carbony...)
Affinity DataKi:  59nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035499((S)-1-[(S)-3-Methyl-2-(2-morpholin-4-yl-acetylamin...)
Affinity DataKi:  60nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035504((S)-1-((S)-2-Benzoylamino-3-methyl-butyryl)-pyrrol...)
Affinity DataKi:  70nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065163((R)-3-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  70nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035493((S)-1-[(S)-3-Methyl-2-(3-morpholin-4-yl-3-oxo-prop...)
Affinity DataKi:  70nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 25 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065155(2-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-benzo...)
Affinity DataKi:  100nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065154(4-Hydroxy-1-{(S)-3-methyl-2-[4-(morpholine-4-carbo...)
Affinity DataKi:  120nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065146(1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-benzo...)
Affinity DataKi:  150nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035490(CHEMBL141517 | Morpholine-4-carboxylic acid {(S)-2...)
Affinity DataKi:  170nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035491(CHEMBL59091 | Morpholine-4-carboxylic acid {(S)-2-...)
Affinity DataKi:  190nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035496((S)-1-{(S)-2-[(Furan-2-carbonyl)-amino]-3-methyl-b...)
Affinity DataKi:  190nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 45 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035491(CHEMBL59091 | Morpholine-4-carboxylic acid {(S)-2-...)
Affinity DataKi:  195nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065164((S)-1-{(R)-3,3-Dimethyl-2-[4-(morpholine-4-carbony...)
Affinity DataKi:  240nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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