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Found 47 with Last Name = 'chuckowree' and Initial = 'is'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Piramed Pharma

LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKi:  580nM ΔG°:  -35.6kJ/molepH: 7.5 T: 2°CAssay Description:Mammalian target of rapamycin (mTOR) was assayed by monitoring phosphorylation of GFP-4EBP using a homogeneous time-resolved fluorescence resonance e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Piramed Pharma

LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328080(3-(6-(1H-indazol-4-yl)-1-methyl-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328082(6-(1H-indazol-4-yl)-1-methyl-N-(4-(methylsulfonyl)...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328076(6-(1H-indazol-4-yl)-N-(3-methoxyphenyl)-1-methyl-1...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328079(6-(1H-indazol-4-yl)-1-methyl-N-(3-(methylsulfonyl)...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328078(CHEMBL1257304 | N-(3-methoxyphenyl)-1-methyl-6-(3-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25021(3-{6-[(dimethylamino)methyl]-4-(morpholin-4-yl)thi...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328083(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25022(3-(6-{[(2-methoxyethyl)(methyl)amino]methyl}-4-(mo...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328084(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25019(3-[6-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25024(3-(6-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25018(3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phe...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328081(6-(1H-indazol-4-yl)-1-methyl-N-(1-methylpiperidin-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25023(3-{6-[(4-methylpiperazin-1-yl)methyl]-4-(morpholin...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328077(6-(3-amino-1H-indazol-4-yl)-N-(3-methoxyphenyl)-1-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328075(6-(2-aminopyrimidin-5-yl)-N-(3-methoxyphenyl)-1-me...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25020(3-[7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Affinity DataIC50:  21nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328074(CHEMBL1258919 | N-(3-methoxyphenyl)-1-methyl-6-(py...)
Affinity DataIC50:  29nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
LigandPNGBDBM25027(4-[2-(1H-indazol-4-yl)-6-[(4-methylpiperazin-1-yl)...)
Affinity DataIC50:  44nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328070(CHEMBL1255605 | N-(3-methoxyphenyl)-1-methyl-6-(3-...)
Affinity DataIC50:  56nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328071(3-(4-(3-methoxyphenylamino)-1-methyl-1H-pyrazolo[3...)
Affinity DataIC50:  72nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  75nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
LigandPNGBDBM50328067(6-(1,1-dioxidothiomorpholin-4-yl)-N-(3-methoxyphen...)
Affinity DataIC50:  75nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25025(4-[2-(1H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl]...)
Affinity DataIC50:  102nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328069(CHEMBL1258578 | N,6-bis(3-methoxyphenyl)-1-methyl-...)
Affinity DataIC50:  134nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328064(CHEMBL1258354 | ETP-7382 | N-(3-methoxyphenyl)-1-m...)
Affinity DataIC50:  162nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  187nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells assessed as phosphorylated Akt levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328068(CHEMBL1258577 | N-(3-methoxyphenyl)-1-methyl-6-(pi...)
Affinity DataIC50:  359nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328066(6-(2,6-dimethylmorpholino)-N-(3-methoxyphenyl)-1-m...)
Affinity DataIC50:  370nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328073(CHEMBL1258805 | N-(3-(4-(3-methoxyphenylamino)-1-m...)
Affinity DataIC50:  386nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328065(1-(4-(3-methoxyphenylamino)-1-methyl-1H-pyrazolo[3...)
Affinity DataIC50:  430nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  670nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50328085(6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)...)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25026(4-[2-(1H-indazol-6-yl)thieno[3,2-d]pyrimidin-4-yl]...)
Affinity DataIC50:  2.45E+3nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50328072(3-(4-(3-methoxyphenylamino)-1-methyl-1H-pyrazolo[3...)
Affinity DataIC50:  3.64E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Piramed Pharma

LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed