Affinity DataKi: 8.5nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataKi: 415nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataKi: 523nMAssay Description:Inhibition of human recombinant pro-MMP7 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of bovine erythrocytes AChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at P2Y12 receptor assessed as inhibition of ADP-induced human platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity of first enantiomer (E1) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at P2Y12 receptor assessed as inhibition of ADP-induced human platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Antagonist activity at P2Y12 receptor assessed as inhibition of ADP-induced human platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Binding affinity of first diastereomer (D1) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
TargetGolgi-associated PDZ and coiled-coil motif-containing protein(Homo sapiens)
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Binding affinity to C-terminal His6 tagged CAL PDZ domain (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hr using FAM-22 probe b...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Binding affinity of second diastereomer (D2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Binding affinity of first diastereomer (D1) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair