Compile Data Set for Download or QSAR
maximum 50k data
Found 522 with Last Name = 'dou' and Initial = 'g'
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  415nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  523nMAssay Description:Inhibition of human recombinant pro-MMP7 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188311(2-(3-(8-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188301(2-(2,5-dimethyl-3-(8-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188300(2-(2,5-dimethyl-3-(7-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  5.40nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50449479(CHEMBL4168520)
Affinity DataIC50:  6nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188305(2-(2,5-dimethyl-3-(8-(trifluoromethyl)quinolin-4-y...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50449479(CHEMBL4168520)
Affinity DataIC50:  6nMAssay Description:Inhibition of bovine erythrocytes AChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188309(2-(3-(8-fluoroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  7.10nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188307(2-(3-(7-chloroquinolin-4-yl)-2,5-dimethyl-1H-indol...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246791(CHEMBL498915 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121047(5-Fluoro-2-[3-(1-hydroxy-ethyl)-2,6-diisopropyl-5-...)
Affinity DataIC50:  10nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50519656(CHEMBL4471701)
Affinity DataIC50:  11nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246790(CHEMBL488617 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188299(2-(3-(8-methoxyquinolin-4-yl)-2,5-dimethyl-1H-indo...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Inspire Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50371580(CHEMBL1162175)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at P2Y12 receptor assessed as inhibition of ADP-induced human platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50519660(CHEMBL4563607)
Affinity DataIC50:  12nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50519658(CHEMBL4534075)
Affinity DataIC50:  12nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50519653(CHEMBL4443840)
Affinity DataIC50:  12nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121049(5-Fluoro-2-[3-(1-hydroxy-ethyl)-2,6-diisopropyl-5-...)
Affinity DataIC50:  12nMAssay Description:Binding affinity of first enantiomer (E1) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Inspire Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50371581(CHEMBL1162179)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at P2Y12 receptor assessed as inhibition of ADP-induced human platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Inspire Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50371580(CHEMBL1162175)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at P2Y12 receptor assessed as inhibition of ADP-induced human platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121045(2-[3-Ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyr...)
Affinity DataIC50:  16nMAssay Description:Binding affinity of first diastereomer (D1) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Inspire Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374555(REGRELOR DISODIUM)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at P2Y12 receptor assessed as platelet aggregation by washed platelet assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121045(2-[3-Ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyr...)
Affinity DataIC50:  16nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246681(CHEMBL474723 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121047(5-Fluoro-2-[3-(1-hydroxy-ethyl)-2,6-diisopropyl-5-...)
Affinity DataIC50:  18nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246797(CHEMBL502674 | N'-{3-(R)-[2-(S)-(2-Phenyl-1H-indol...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant pro-MMP9 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188314(2-(2,5-dimethyl-3-(2-methylquinolin-4-yl)-1H-indol...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188308(2-(3-(8-cyanoquinolin-4-yl)-2,5-dimethyl-1H-indol-...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50449485(CHEMBL4160280)
Affinity DataIC50:  20nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50449482(CHEMBL4176452)
Affinity DataIC50:  20nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGolgi-associated PDZ and coiled-coil motif-containing protein(Homo sapiens)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50555255(CHEMBL4777388)
Affinity DataIC50:  20nMAssay Description:Binding affinity to C-terminal His6 tagged CAL PDZ domain (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hr using FAM-22 probe b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121045(2-[3-Ethyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyr...)
Affinity DataIC50:  20nMAssay Description:Binding affinity of second diastereomer (D2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50238212(CHEMBL4077952)
Affinity DataIC50:  20nMAssay Description:Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured eve...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188313(2-(2,5-dimethyl-3-(quinolin-4-yl)-1H-indol-1-yl)ac...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50188310(2-(2,5-dimethyl-3-(8-(methylsulfonyl)quinolin-4-yl...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50519657(CHEMBL4585112)
Affinity DataIC50:  24nMAssay Description:Displacement of TMR-labelled PDI from human GST tagged MDM2 (1 to 139 residues) expressed in Escherichia coli BL21 (DE3) cells preincuabted for 1 hr ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50246680(CHEMBL474523 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant pro-MMP2 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121046(2-[3-(1-Hydroxy-ethyl)-2,6-diisopropyl-5-propyl-py...)
Affinity DataIC50:  25nMAssay Description:Binding affinity of first diastereomer (D1) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50121048(2-[3-Butyl-5-(1-hydroxy-ethyl)-2,6-diisopropyl-pyr...)
Affinity DataIC50:  28nMAssay Description:Binding affinity of second enantiomer (E2) of the compound against human glucagon receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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