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Found 38 with Last Name = 'hergenrother' and Initial = 'pj'
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339607(1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...)
Affinity DataKi:  4.70E+3nMAssay Description:Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50066974(7-Benzyl-2,3-dihydroxy-6-methyl-4-propyl-naphthale...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339607(1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...)
Affinity DataKi:  8.90E+3nMAssay Description:Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339605(1-Hydroxy-5-phenyl-1H-indole-2-carboxylic Acid | C...)
Affinity DataKi:  1.04E+4nMAssay Description:Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339605(1-Hydroxy-5-phenyl-1H-indole-2-carboxylic Acid | C...)
Affinity DataKi:  1.57E+4nMAssay Description:Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339606(1-Hydroxy-6-phenyl-1H-indole-2-carboxylic Acid | C...)
Affinity DataKi:  1.98E+4nMAssay Description:Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339606(1-Hydroxy-6-phenyl-1H-indole-2-carboxylic Acid | C...)
Affinity DataKi:  3.54E+4nMAssay Description:Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM23222(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Affinity DataKi:  1.38E+5nMAssay Description:Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM23251(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM23242(1,2(1,5)-Isoxazole, IOA1 | 3-hydroxy-1,2-oxazole-4...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
University of Illinois

LigandPNGBDBM36363(CID6851947 | PAC-1 | US10166229, Example PAC-1)
Affinity DataEC50:  4.50E+3nMpH: 7.4 T: 2°CAssay Description:Procaspase-7 activation assay; activation of procaspase-7 to caspase-7. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM79403(3-aminopropyl-[4-(3-aminopropylamino)butyl]amine;h...)
Affinity DataEC50:  8.50E+3nMAssay Description:Activation of procaspase 2 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50376458(CHEMBL259148)
Affinity DataEC50:  5.00E+4nMAssay Description:Activation of procaspase 2 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50376459(CHEMBL409053)
Affinity DataEC50:  2.50E+4nMAssay Description:Activation of procaspase 2 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50376460(CHEMBL411858)
Affinity DataEC50:  2.50E+4nMAssay Description:Activation of procaspase 2 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50376461(CHEMBL262596)
Affinity DataEC50:  5.00E+4nMAssay Description:Activation of procaspase 2 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50376462(CHEMBL265439)
Affinity DataEC50:  6.60E+4nMAssay Description:Activation of procaspase 2 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM80992(1-cetylpyridin-1-ium;bromide | 1-hexadecylpyridin-...)
Affinity DataEC50:  2.10E+4nMAssay Description:Activation of procaspase 2 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36363(CID6851947 | PAC-1 | US10166229, Example PAC-1)
Affinity DataEC50:  220nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36364(CID9543559 | De-ally PAC-1 | US10166229, Example d...)
Affinity DataEC50:  430nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36365((4-Benzylpiperazin-1-yl)-acetic acid benzylidene-h...)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM312057(US10166229, Example 00027)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM312058(US10166229, Example 00028)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36368((4-Benzylpiperazin-1-yl)-acetic acid hydrazide, 6 ...)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36369((4-Benzylpiperazin-1-yl)-acetic acid ethyl ester, ...)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36370(CID207112 | Piperazin-1-yl-acetic acid ethyl ester...)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM50125096(1,4-Dibenzyl-piperazine | 1,4-Dibenzyl-piperazine,...)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM50004308(1-Benzoylpiperazine | 1-Benzyl-piperazine | 1-Benz...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM50125096(1,4-Dibenzyl-piperazine | 1,4-Dibenzyl-piperazine,...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36370(CID207112 | Piperazin-1-yl-acetic acid ethyl ester...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36369((4-Benzylpiperazin-1-yl)-acetic acid ethyl ester, ...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36368((4-Benzylpiperazin-1-yl)-acetic acid hydrazide, 6 ...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36367((4-Benzylpiperazin-1-yl)-acetic acid ethylidene-hy...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36366((4-Methylpiperazin-1-yl)-acetic acid (2-hydroxy-be...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36365((4-Benzylpiperazin-1-yl)-acetic acid benzylidene-h...)
Affinity DataEC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM50004308(1-Benzoylpiperazine | 1-Benzyl-piperazine | 1-Benz...)
Affinity DataEC50: >5.00E+4nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36363(CID6851947 | PAC-1 | US10166229, Example PAC-1)
Affinity DataEC50:  220nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University of Illinois

US Patent
LigandPNGBDBM36364(CID9543559 | De-ally PAC-1 | US10166229, Example d...)
Affinity DataEC50:  430nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed