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Found 29 with Last Name = 'igarashi' and Initial = 'm'
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM50428367(CHEMBL2332119 | Vegfrecine)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Flt4 (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292705((25R)-25-Adamantyl-1alpha,25-dihydroxy-2-methylene...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at VDR expressed in COS7 cells assessed as inhibition of 1,25-Dihydroxyvitamin D3-induced response by transient transcription ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM50428367(CHEMBL2332119 | Vegfrecine)
Affinity DataIC50:  11nMAssay Description:Inhibition of KDR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM50428367(CHEMBL2332119 | Vegfrecine)
Affinity DataIC50:  18nMAssay Description:Inhibition of GST-Flt1 kinase domain (unknown origin) expressed in baculovirus infected Sf9 cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292704((1R,3R,7E,17beta)-17-{(1S,2E,5R)-5-hydroxy-1-methy...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at VDR expressed in COS7 cells assessed as inhibition of 1,25-Dihydroxyvitamin D3-induced response by transient transcription ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PDGFR-alpha (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of PDGFR-beta (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM50428367(CHEMBL2332119 | Vegfrecine)
Affinity DataIC50:  480nMAssay Description:Inhibition of PDGFR-beta (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Flt4 (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM50428367(CHEMBL2332119 | Vegfrecine)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of EGFR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of GST-Flt1 kinase domain (unknown origin) expressed in baculovirus infected Sf9 cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM50428367(CHEMBL2332119 | Vegfrecine)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of PDGFR-alpha (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50004907(2-Amino-3-(4-phosphonomethyl-phenyl)-propionic aci...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory activity against Syk C-terminal SH2 domain in in-silico screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107899(2-[4-(4-{2-[(5-Carboxy-pentyl)-(3-cyclohexyl-propy...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107897(2-[4-(4-{2-[(5-Carboxy-pentyl)-(3-cyclohexyl-propy...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107901(2-[4-(4-{2-[(5-Carboxy-pentyl)-(3-cyclohexyl-propy...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107900(2-[4-(4-{2-[(5-Carboxy-pentyl)-(5-methyl-hexyl)-su...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107902(2-[4-(4-{2-[(5-Carboxy-pentyl)-(5-methyl-hexyl)-su...)
Affinity DataIC50:  6.90E+4nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107898(2-[4-(4-{2-[(5-Carboxy-pentyl)-(5-methyl-hexyl)-su...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Institute Of Microbial Chemistry (Bikaken)

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of EGFR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107895(2-(4-{4-[2-(5-Carboxy-pentylsulfamoyl)-vinyl]-phen...)
Affinity DataIC50:  3.50E+5nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107903(2-Cyclohexyl-malonic acid | CHEMBL142870)
Affinity DataIC50:  5.90E+6nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107894(2-Cyclooct-4-enyl-malonic acid | CHEMBL357125)
Affinity DataIC50:  7.70E+6nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50107896(6-(2-Phenyl-ethenesulfonylamino)-hexanoic acid | C...)
Affinity DataIC50:  8.00E+6nMAssay Description:Inhibitory activity against Syk C-terminal SH2 (at 10 mM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM14676(2-phenylpropanedioic acid | CHEMBL78794 | Fragment...)
Affinity DataIC50:  1.20E+7nMAssay Description:Inhibitory activity against Syk C-terminal SH2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292705((25R)-25-Adamantyl-1alpha,25-dihydroxy-2-methylene...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at VDR assessed as receptor transactivation by transient transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292704((1R,3R,7E,17beta)-17-{(1S,2E,5R)-5-hydroxy-1-methy...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at VDR assessed as receptor transactivation by transient transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292706((1R,3R,7E,17beta)-17-{(1R,2E,4R)-4-hydroxy-1-methy...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at VDR assessed as receptor transactivation by transient transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed