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Found 133 with Last Name = 'leone' and Initial = 'd'
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110551(CHEMBL352291 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110543(CHEMBL167396 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110557(CHEMBL352380 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110555(CHEMBL164935 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110546(CHEMBL165377 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110540(Benzoic acid 2-[4-((R)-4-{(S)-1-[4-(benzo[1,3]diox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110553(CHEMBL349142 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110542(CHEMBL167816 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110547(CHEMBL165035 | [4-((R)-3-Methyl-4-{(S)-1-[4-(tolue...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110550((2-Amino-phenyl)-[4-((R)-4-{(S)-1-[4-(benzo[1,3]di...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110556(CHEMBL354534 | [4-((R)-4-{(S)-1-[4-(2,4-Dimethoxy-...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110530(CHEMBL349720 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103087(CHEMBL305026 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110559(CHEMBL110744 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110560(CHEMBL165434 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110552(CHEMBL353842 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110544(CHEMBL354461 | [4-((R)-3-Methyl-4-{(S)-1-[4-(3-tri...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110558(CHEMBL167629 | [4-((R)-4-{(S)-1-[4-(4-Methoxy-benz...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110548(CHEMBL167838 | [4-((R)-4-{(S)-1-[4-(4-Methoxy-benz...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110554(CHEMBL166685 | N-{2-[4-((R)-4-{(S)-1-[4-(Benzo[1,3...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110549(CHEMBL167839 | [4-((R)-4-{(S)-1-[4-(7-Methoxy-benz...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110561(CHEMBL350404 | [4-((R)-4-{(S)-1-[4-(6-Methoxy-benz...)
Affinity DataKi:  53nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110541(CHEMBL164385 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  77nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110545(CHEMBL163686 | [4-((R)-3-Methyl-4-{(S)-1-[4-(2,3,4...)
Affinity DataKi:  442nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074659((S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[4-(3-o-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50422305(CHEMBL1791268)
Affinity DataIC50:  1nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50:  1nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074664((S)-N-[(S)-1-((S)-2-Carbamoyl-pyrrolidine-1-carbon...)
Affinity DataIC50:  1nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595862(CHEMBL5189924)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595862(CHEMBL5189924)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595859(CHEMBL5192731)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074660((S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[4-(3-ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595859(CHEMBL5192731)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074658((S)-1-{(S)-2-[(S)-2-((S)-6-(6-Amino-hexanoylamino)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of integrin alpha4-beta1 adhesion to Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50422305(CHEMBL1791268)
Affinity DataIC50:  5nMAssay Description:Inhibition of integrin alpha4-beta1 adhesion to Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074659((S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[4-(3-o-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of integrin alpha4-beta1 adhesion to Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595863(CHEMBL5184022)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595864(CHEMBL5208387)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074664((S)-N-[(S)-1-((S)-2-Carbamoyl-pyrrolidine-1-carbon...)
Affinity DataIC50:  8nMAssay Description:Inhibition of integrin alpha4-beta1 adhesion to Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595863(CHEMBL5184022)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505256(CHEMBL4547737)
Affinity DataIC50:  18nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074668((S)-2-((S)-4-Methyl-2-{2-[4-(3-o-tolyl-ureido)-phe...)
Affinity DataIC50:  18nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074658((S)-1-{(S)-2-[(S)-2-((S)-6-(6-Amino-hexanoylamino)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of integrin alpha4-beta1 adhesion to Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074660((S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[4-(3-ph...)
Affinity DataIC50:  30nMAssay Description:Inhibition of integrin alpha4-beta1 adhesion to Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50074666((S)-2-((S)-2-{(S)-2-[2-(4-Benzyloxycarbonylamino-p...)
Affinity DataIC50:  30nMAssay Description:Inhibition of integrin alpha4-beta1 binding to VCAM-IgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595856(CHEMBL5205795)
Affinity DataIC50:  32nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595857(CHEMBL5192925)
Affinity DataIC50:  33nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595858(CHEMBL5204844)
Affinity DataIC50:  51nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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